戴建武，博士，研究员，博士生导师。

教育经历及任职：

1984-1988年  武汉大学生物系细胞生物学专业  学士

1988-1991年  北京医科大学生物物理学专业  硕士

1996-1998年  美国杜克大学细胞生物学专业  博士

1998-2000年  哈佛大学医学院  博士后研究

2022年-至今  中国医学科学院生物医学工程研究所特聘研究员，执行所长，整合再生医学实验室负责人

2003年-至今  中国科学院遗传与发育生物学研究所研究员，再生医学研究中心主任

社会兼职：

国家食品药品监督管理局医疗器械审评专家

中国细胞生物学学会干细胞分会副会长兼秘书长

中国生物材料学会神经再生修复材料副会长

中国遗传学会再生医学转化分会常务副会长

Biomedical Materials杂志主编

Science China Life Sciences 杂志编委

主要研究方向：

研究磁、声、光、电等物理信号对组织器官发育及再生的影响，探索物理信号对组织器官发育与再生的作用机制。通过整合物理信号与化学信号的作用，建立引导组织器官再生的微环境，研发组织器官再生的新技术、新产品。

近3年基金项目：

2023-2027年  国家重点研发计划“诊疗装备与生物医用材料”重点专项，“脊髓损伤修复生物材料产品研发”项目，项目负责人

2024-2028年 国家自然科学基金重点项目“仿生/工程化脊髓组织构建与功能调控”，项目负责人

2002-2007年 中国医学科学院医学与健康科技创新工程，医学健康领军科技人才养募专项“脊髓发育的调控与脊髓损伤再生微环境重建”，项目负责人

荣誉及获奖情况：

2006年  国家杰出青年基金获得者

2012年  心肌梗死后心肌组织修复和功能重建的机制研究及临床应用，国家科技部，国家科学技术进步奖二等奖

2014年  中央电视台年度科技创新人物

2016年  第六届中国侨界再生医学创新成果奖

2017年  中国细胞生物学学会干细胞生物学分会干细胞成果转化奖

2018年  子宫内膜再生研究获江苏省科学技术一等奖

代表性成果：

1. 突破了再生医学关键技术。研发了系列具有自主知识产权的再生医学产品。研发的基于胶原蛋白特异结合的BMP2活性骨材料成功获得创新医疗器械注册证，实现了0-1的突破。提出组织内源干细胞的激活与分化是组织再生的重要机理。率先成功组织了包括子宫内膜再生、卵巢再生、脊髓损伤再生，心肌再生等多个产品的临床研究。

2. 研发的子宫内膜再生修复产品为子宫内膜损伤的不孕患者提供了一种有效的治疗手段，入选2014年中央电视台年度科技创新人物；卵巢再生修复取得突破，第一个卵巢早衰患者2018年1月12日诞生世界上首位健康宝宝。子宫内膜再生卵巢再生及脊髓损伤再生成果入选国家改革开放40周年创新成果展。

3. 成功研发了首个脊髓损伤再生修复产品NeuroRegn支架。NeuroRegn支架2014年开始临床研究，长期的临床随访结果表明NeuroRegn支架治疗急性及陈旧性脊髓损伤安全有效。研究团队成为国际上最受关注的脊髓损伤再生修复研究团队之一。

近3年代表论著：

1. Sun Z, Chen Z, Yin M, Wu X, Guo B, Cheng X, Quan R, Sun Y, Zhang Q, Fan Y, Jin C, Yin Y, Hou X, Liu W, Shu M, Xue X, Shi Y, Chen B, Xiao Z, Dai J.*, Zhao Y.*. Harnessing developmental dynamics of spinal cord extracellular matrix improves regenerative potential of spinal cord organoids. Cell Stem Cell. 2024, 31(5):772-787.

2. Liu Z, Lai J, Kong D, Zhao Y.*, Zhao J, Dai J.*, Zhang M.*. Advances in electroactive bioscaffolds for repairing spinal cord injury. Biomed Mater. 2024, 19(3): 032005.

3. Sun Y, Xiao Z, Chen B, Zhao Y, Dai J.*. Advances in Material-Assisted Electromagnetic Neural Stimulation. Adv Mater. 2024, e2400346.

4. Wu Z, Zhou Y, Hou X, Liu W, Yin W, Wang L, Cao Y, Jiang Z, Guo Y, Chen Q, Xie W, Wang Z, Shi N, Liu Y, Gao X.*, Luo L.*, Dai J.*, Ren C.*, Jiang X.*. Construction of functional neural network tissue combining CBD-NT3-modified linear-ordered collagen scaffold and TrkC-modified iPSC-derived neural stem cells for spinal cord injury repair. Bioact Mater. 2024, 35:242-258.

5. Fan C, Cai H, Zhang L, Wu X, Yan J, Jin L, Hu B, He J, Chen Y.*, Zhao Y.*, Dai J.*. Constructing Linear-Oriented Pre-Vascularized Human Spinal Cord Tissues for Spinal Cord Injury Repair. Adv Healthc Mater. 2024, e2303388.

6. Fan Y, Wu X, Han S, Zhang Q, Sun Z, Chen B, Xue X, Zhang H, Chen Z, Yin M, Xiao Z.*, Zhao Y.*, Dai J.*. Single-cell analysis reveals region-heterogeneous responses in rhesus monkey spinal cord with complete injury. Nat Commun. 2023, 14(1): 4796.

7. You Z, Gao X, Kang X, Yang W, Xiong T, Li Y, Wei F, Zhuang Y, Zhang T, Sun Y, Shen H.*, Dai J.*. Microvascular endothelial cells derived from spinal cord promote spinal cord injury repair. Bioact Mater. 2023, 29: 36-49.

8. Xu B, Liu D, Liu W, Long G, Liu W, Wu Y, He X, Shen Y, Jiang P, Yin M, Fan Y, Shen H, Shi L, Zhang Q, Xue W, Jin C, Chen Z, Chen B, Li J, Hu Y, Li X.*, Xiao Z.*, Zhao Y.*, Dai J.*. Engineered human spinal cord-like tissues with dorsal and ventral neuronal progenitors for spinal cord injury repair in rats and monkeys. Bioact Mater. 2023, 27: 125-137.

9. Chen Z, Sun Z, Fan Y, Yin M, Jin C, Guo B, Yin Y, Quan R, Zhao S, Han S, Cheng X, Liu W, Chen B, Xiao Z, Dai J.*, Zhao Y.*. Mimicked Spinal Cord Fibers Trigger Axonal Regeneration and Remyelination after Injury. ACS Nano. 2023, 17(24): 25591-25613.

10. Xiong T, Yang K, Zhao T, Zhao H, Gao X, You Z, Fan C, Kang X, Yang W, Zhuang Y, Chen Y, Dai, J.* Multifunctional Integrated Nanozymes Facilitate Spinal Cord Regeneration by Remodeling the Extrinsic Neural Environment. Adv Sci. 2023, e2205997.

11. Liu W, Xu B, Zhao S, Han S, Quan R, Liu W, Ji C, Chen B, Xiao Z, Yin M, Yin Y, Dai, J.* Zhao Y.*, Spinal cord tissue engineering via covalent interaction between biomaterials and cells. Sci Adv. 2023, 9(6): eade8829.

12. Wang X, Hou X, Zhao Y, Zhao R, Dai, J.* Dai H, Wang C. The early and late intervention effects of collagen-binding FGF2 on elastase-induced lung injury. Biomed Pharmacother. 2023, 158: 114147.

13. Qian L, Yang K, Liu X, Zhang L, Zhao H, Qiu LZ, Chu Y, Hao W, Zhuang Y, Chen Y, Dai, J.* Baicalein-functionalized collagen scaffolds direct neuronal differentiation toward enhancing spinal cord injury repair. Biomater Sci. 2023, 11(2): 678-689.

14. Yang W, Kang X, Gao X, Zhuang Y, Fan C, Shen H, Chen Y*, Dai, J.* Biomimetic Natural Biopolymer-Based Wet-Tissue Adhesive for Tough Adhesion, Seamless Sealed, Emergency/Nonpressing Hemostasis, and Promoted Wound Healing. Adv. Funct. Mater. 2023, 33, 2211340.

15. Gao X, You Z, Li Y, Kang X, Yang W, Wang H, Zhang T, Zhao X, Sun Y, Shen H*, Dai, J.* Multifunctional hydrogel modulates the immune microenvironment to improve allogeneic spinal cord tissue survival for complete spinal cord injury repair. Acta Biomaterialia 2023, 155: 235-246.

16. Wang Z, Li Y, Sun C, Cui P, Han Y, Wu T, Xu B, Zhang C, Shi L*, Dai, J.* Locally controlled release of immunosuppressive promotes survival of transplanted adult spinal cord tissue. Regen Biomater. 2022, 10: rbac097.

17. Shu M, Hong D, Lin H, Zhang J, Luo Z, Du Y, Sun Z, Yin M, Yin Y, Liu L, Bao S, Liu Z, Lu F*, Huang J*, Dai, J.* Single-cell chromatin accessibility identifies enhancer networks driving gene expression during spinal cord development in mouse. Dev Cell. 2022, 57(24): 2761-2775.e6.

18. Hong D, Lin H, Liu L, Dai J, Lu F, Tong M, Huang J*. Complexity of enhancer networks predicts cell identity and disease genes revealed by single-cell multi-omics analysis. Brief Bioinform. 2023, 24(1): bbac508.

19. Xu B, Yin M, Yang Y, Zou Y, Liu W, Qiao L, Zhang J, Wang Z, Wu Y, Shen H, Sun M, Liu W, Xue W, Fan Y, Zhang Q, Chen B, Wu X, Shi Y, Lu F, Zhao Y, Xiao Z, Dai, J.* Transplantation of neural stem progenitor cells from different sources for severe spinal cord injury repair in rat. Bioact Mater. 2022, 23: 300-313.

20. Zhuang Y, Yang W, Zhang L, Fan C, Qiu L, Zhao Y, Chen B, Chen Y*, Shen H*, Dai, J.* A novel leptin receptor binding peptide tethered-collagen scaffold promotes lung injury repair. Biomaterials. 2022, 291: 121884.

21. Liu X, Zhang L, Xu Z, Xiong X, Yu Y, Wu H, Qiao H, Zhong J, Zhao Z, Dai, J.*, Suo G. A functionalized collagen-I scaffold delivers microRNA 21-loaded exosomes for spinal cord injury repair. Acta Biomater. 2022, 154: 385-400.

22. Ma D, Shen H, Chen F, Liu W, Zhao Y, Xiao Z, Wu X, Chen B, Lu J, Shao D, Dai, J.*. Inflammatory Microenvironment-Responsive Nanomaterials Promote Spinal Cord Injury Repair by Targeting IRF5. Adv Healthc Mater. 2022, 11(23): e2201319.

23. Jin C, Wu Y, Zhang H, Xu B, Liu W, Ji C, Li P, Chen Z, Chen B, Li J, Wu X, Jiang p, Hu Y, Xiao Z*, Zhao Y*, Dai, J.*. Spinal cord tissue engineering using human primary neural progenitor cells and astrocytes. Bioeng Transl Med. 2022, e10448.

24. Jia W, Zhu H, Zhao M, Zhou Q, Yin W, Liu W, Wang L, Xiao Z, Jiang X, Dai, J.* Ren C*. Potential mechanisms underlying the promoting effects of 3D collagen scaffold culture on stemness and drug resistance of glioma cells. Biochim Biophys Acta Mol Basis Dis. 2022, 1868(11): 166522.

25. Fan C, Yang W, Zhang L, Cai H, Zhuang Y, Chen Y, Zhao Y, Dai, J.*. Restoration of spinal cord biophysical microenvironment for enhancing tissue repair by injury-responsive smart hydrogel. Biomaterials. 2022, 288: 121689.

26. Zeng Y, Zhang C, Du D, Li Y, Sun L, Han Y, He X, Dai, J.* Shi L*. Metal-organic framework-based hydrogel with structurally dynamic properties as a stimuli-responsive localized drug delivery system for cancer therapy. Acta Biomater. 2022, 145: 43-51.

27. Tang F, Tang J, Zhao Y, Zhang J, Xiao Z, Chen B, Han G, Yin N, Jiang X, Zhao C, Cheng S, Wang Z, Chen Y, Chen Q, Song K, Zhang Z, Niu J, Wang L, Shi Q, Chen L, Yang H, Hou S, Zhang S, Dai, J.*. Long-term clinical observation of patients with acute and chronic complete spinal cord injury after transplantation of NeuroRegen scaffold. Sci China Life Sci. 2022, 65(5): 909-926.

28. Xue X, Shu M, Xiao Z, Zhao Y, Li X, Zhang H, Fan Y, Wu X, Chen B, Xu B, Yang Y, Liu W, Liu S, Dai, J.*. Lineage tracing reveals the origin of Nestin-positive cells are heterogeneous and rarely from ependymal cells after spinal cord injury. Sci China Life Sci. 2022, 65(4): 757-769.

29. Zhou Z, Wang H, Zhang X, Song M, Yao S, Jiang P, Liu D, Wang Z, Lv H, Li R, Hong Y, Dai, J.* Hu Y*, Zhao G*. Defective autophagy contributes to endometrial epithelial-mesenchymal transition in intrauterine adhesions. Autophagy. 2022: 1-16.

30. Han Y, Sun L, Wen C, Wang Z*, Dai, J.*, Shi L*. Flexible conductive silk-PPy hydrogel toward wearable electronic strain sensors. Biomed Mater. 2022, 17(2): 024107.

31. Lv H, Zhao G, Jiang P, Wang H, Wang Z, Yao S, Zhou Z, Wang L, Liu D, Deng W, Dai, J.*, Hu Y*. Deciphering the endometrial niche of human thin endometrium at single-cell resolution. Proc Natl Acad Sci U S A. 2022, 119(8): e2115912119.

32. Zou Y, Yin Y, Xiao Z, Zhao Y, Han J, Chen B, Xu B, Cui Y, Ma X, Dai, J.*. Transplantation of collagen sponge-based three-dimensional neural stem cells cultured in a RCCS facilitates locomotor functional recovery in spinal cord injury animals. Biomater Sci. 2022, 10(4): 915-924.

33. Yin Z, Sun L, Shi L, Nie H, Dai, J.*, Zhang C*. Bioinspired bimodal micro-nanofibrous scaffolds promote the tenogenic differentiation of tendon stem/progenitor cells for achilles tendon regeneration. Biomater Sci. 2022, 10(3): 753-769.

34. Zhao X, Wang H, Zou Y, Xue W, Zhuang Y, Gu R, Shen H, Dai, J.* Optimized, visible light-induced crosslinkable hybrid gelatin/hyaluronic acid scaffold promotes complete spinal cord injury repair. Biomed Mater. 2022, 17(2): 024104.

35. Chen Z, Zhang H, Fan C, Zhuang Y, Yang W, Chen Y, Shen H, Xiao Z, Zhao Y*, Li X*, Dai, J.* Adhesive, Stretchable, and Spatiotemporal Delivery Fibrous Hydrogels Harness Endogenous Neural Stem/Progenitor Cells for Spinal Cord Injury Repair. ACS Nano. 2022, 16(2): 1986-1998.

36. Shen H, Xu B, Yang C, Xue W, You Z, Wu X, Ma D, Shao D, Leong K, Dai, J.* A DAMP-scavenging, IL-10-releasing hydrogel promotes neural regeneration and motor function recovery after spinal cord injury. Biomaterials. 2022, 280: 121279.