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李稳
研究员,博士生导师

李稳,研究员,博士生导师

研究领域:性能可控的诊疗生物材料构建及其在重大疾病高效和精准治疗方面的应用

研究兴趣:1)构建可跨越生物屏障的靶向纳米递送系统促进基因药物的脑部运输和脑损伤的治疗;2)构建性能可动态改变的响应性生物材料用于准确调控治疗基元的功能,实现因需可控治疗;3)开发高清纳米探针用于原位成像引导的精准肿瘤手术切除和联合免疫治疗。

教育背景

2010-2016 中国科学院长春应用化学研究所, 硕博连读(导师:曲晓刚研究员)

2006-2010 南京师范大学,化学专业

工作经历

2021.08-至今 生物医学工程研究所,研究员,博士生导师

2016-2020 美国麻省理工学院, 博士后(导师 Robert Langer院士)

荣誉与奖励:中科院院长优秀奖,优秀博士论文

主要研究成果、代表性论文/著作

目前以通讯作者或第一作者身份发表SCI论文17篇,包括Sci. Adv.Nat. Commun.2篇), Chem. Soc. Rev.J. Am. Chem. Soc.Angew. Chem. Int. Ed.2篇),Adv. Mater.ACS NaonoAdv. Funct. Mater.2篇)等国际知名期刊。其中,中科院分区一区论文13篇,影响因子大于15SCI 论文11篇,申请/授权发明专利4项,包括国际专利一项。研究成果受到国内外同行包括多位院士专家的高度评价,并被 EurekAlert!Science DailyMedicalXpress等权威科学新闻网和美国NIH官网等宣传报道。发表部分研究论文包括:

1. Yuan Zhang#, Xiaoying Kang#, Jia Li, Jianwen Song, Xueping Li, Wen Li*; Ji Qi*, Inflammation-Responsive Nanoagents for Activatable Photoacoustic Molecular Imaging and Tandem Therapies in Rheumatoid Arthritis, ACS Nano, 2024.

2. Jianwen Song#, Xiaoying Kang, Lu Wang, Dan Ding, Deling Kong*, Wen Li*, Ji Qi*, Near-infrared-II photoacoustic imaging and photo-triggered synergistic treatment of thrombosis via fibrin-specific homopolymer nanoparticles, Nat. Commun., 2023, 14, 6881.

3. Xiaoying Kang#, Yuan Zhang#, Jianwen Song, Lu Wang, Wen Li*, Ji Qi*, Ben Zhong Tang*, A photo-triggered self-accelerated nanoplatform for multifunctional imageguided combination cancer immunotherapy. Nat. Commun., 2023, 14, 5216.

4. Wen Li#, Jingtian Zhang, Zhiyuan Gao, Ji Qi*, Dan Ding*, Advancing biomedical applications via manipulating intersystem Crossing, Coord. Chem. Rev., 2022, 471, 214754.

5. Jisen Li#, Guo-Qiang Zhang#, Yufan Zhang, Youhong Tang, Dan Ding, Wen Li,* and Qian Liu*, Building Highly Light-Harvesting Near-Infrared AIEgens Using Triazole-Based Luminescent Core for Improved Intravital Afterglow Imaging, Adv. Funct. Mater., 2023, 33, 2212380.

6. Wen Li#, Jianhua Qiu, Xiang-Ling Li, Sezin Aday, Jingdong Zhang, Grace Conley, Jun Xu, Robert Langer, Rebekah Mannix*, Jeffrey M. Karp*, Nitin Joshi*, BBB pathophysiology independent delivery of siRNA in traumatic brain injury, Sci. Adv., 2021, 7, eabd6889.

7. Zhizhao Miao#, Jisen Li#, Sheng Zeng, Yonghui Lv, Shaorui Jia, Dan Ding, Wen Li*, and Qian Liu*, Endoplasmic Reticulum-Targeting AIE Photosensitizers to Boost Immunogenic Cell Death for Immunotherapy of Bladder Carcinoma, ACS Appl. Mater. Interfaces, 2024, 10.1021/acsami.3c14068.

8. Wen Li#, Zhengqing Yan, Jinsong Ren, Xiaogang Qu*, Manipulating cell fate: dynamic control of cell behaviors on functional platforms, Chem. Soc. Rev., 2018, 47, 8639-8684.

9. Wen Li#, Kai Dong, Jinsong Ren, Xiaogang Qu*, A β-Lactamase‐Imprinted Responsive Hydrogel for the Treatment of Antibiotic-Resistant Bacteria, Angew. Chem. Int. Ed., 2016, 55, 8049–8053.

10. Wen Li#, Wei Bing, Sa Huang, Jinsong Ren and Xiaogang Qu*, Mussel Byssus-like Reversible Metal-chelated Supramolecular Complex Used for Dynamic Cellular Surface Engineering and Imaging. Adv. Funct. Mater., 2015, 25, 3775-3784.

11. Wen Li#, Jiasi Wang, Jinsong Ren, Xiaogang Qu*, Endogenous signalling control of cell adhesion by using aptamer functionalized biocompatible hydrogel, Chem. Sci., 2015, 6, 6762–6768.

12. Wen Li#, Jiasi Wang, Jinsong Ren, Xiaogang Qu*, Near-Infrared Upconversion Controls Photocaged Cell Adhesion. J. Am. Chem. Soc., 2014, 136, 2248-2251.

13. Wen Li#, Jiasi Wang, Jinsong Ren, Xiaogang Qu*, 3D Graphene Oxide-Polymer Hydrogel: Near Infrared Light-Triggered Active Scaffold for Reversible Cell Capture and on-demand Release. Adv. Mater., 2013, 25, 6737-6743.

14. Wen Li#, Jiasi Wang, Jinsong Ren, Xiaogang Qu*, Near-Infrared- and pH-Responsive System for Reversible Cell Adhesion using Graphene/Gold Nanorods Functionalized with i-Motif DNA. Angew. Chem. Int. Ed., 2013, 52, 6726-6730.

实验室成员

助理研究员1名,博士后3名,硕士博士研究生7



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