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马桂蕾
研究员,硕士生导师

马桂蕾,研究员,博士研究生导师,北京协和医学院“协和新星”人才项目、天津市杰出青年科学基金项目获得者。

以第一或通讯作者在相关研究工作发表学术论文30 余篇;累计公开中国发明专利10项(授权7项)。主持国家自然科学基金面上项目(2项),国家自然科学基金青年基金项目,天津市应用基础面上研究项目,教育部新教师基金项目,北京协和医学院青年教师项目等多项科研项目,于2017年获得天津市杰出青年科学基金项目支持(资助经费100万元)。担任《国际生物医学工程杂志》编辑部主任,天津市血液与再生医学学会期刊专业委员会常务委员,中国医药生物技术协会纳米生物技术分会委员会委员。

研究领域:

本人主要研究方向为生物材料和肿瘤纳米技术。利用纳米材料独特的理化性质,围绕肿瘤诊疗领域的技术问题,在基于纳米递送技术的肿瘤免疫治疗方面开展了系列研究,构建多种纳米递药系统以及微/纳颗粒疫苗,探索肿瘤免疫治疗新方法及新策略。

代表性成果:

1. Gong Yonghua#, Zhang Jinyang#, Lu Yan, Wan Dong, Pan Jie*, Ma Guilei*. Light-activated arginine-rich peptide-modified nanoparticles for deep-penetrating chemo-photo-immunotherapy of solid tumor. Nano Research, 2023, 16: 9804-9814IF=10.263

2. Yan Lu, Yonghua Gong , Xianghui Zhu , Xia Dong , Dunwan Zhu, Guilei Ma* . Design of Light-Activated Nanoplatform through Boosting "Eat Me" Signals for Improved CD47-Blocking Immunotherapy. Advanced Healthcare Materials, 2022, 11, 2102712.IF=11.092

3. Xianghui Zhu, Chao Li, Yan Lu, Yijia Liu, Dong Wan, Dunwan Zhu, Jie Pan, Guilei Ma*. Tumor microenvironment-activated therapeutic peptide-conjugated prodrug nanoparticles for enhanced tumor penetration and local T cell activation in the tumor microenvironment. Acta Biomaterialia, 2021, 119: 337-348.IF=10.633

4. Yijia Liu, Yan Lu, Xianghui Zhu, Chao Li, Mengmeng Yan, Jie Pan, Guilei Ma*. Tumor microenvironment-responsive prodrug nanoplatform via co-self-assembly of photothermal agent and IDO inhibitor for enhanced tumor penetration and cancer immunotherapy, Biomaterials, 2020, 242: 119933.IF=10.317

5. Mengmeng Yan, Yijia Liu, Xianghui Zhu, Xiaoli Wang, Lanxia Liu, Hongfan Sun, Chun Wang, Deling Kong, Guilei Ma*. Nanoscale reduced graphene oxide-mediated photothermal therapy together with IDO inhibition and PD-L1 blockade synergistically promote antitumor immunity. ACS Applied Materials & Interfaces, 2019, 11: 1876-1885.IF=8.758 

6. Xiaoli Wang, Fengqiang Cao, Mengmeng Yan, Yijia Liu, Xianghui Zhu, Hongfan Sun, Guilei Ma*. Alum functionalized graphene oxide nanocomplexes for effective anticancer vaccination, Acta Biomaterialia, 2019, 83:390-399.IF=7.242

7. Xiaoli Wang, Zuoguan Chen, Chao Zhang, Chuangnian Zhang, Guilei Ma*. Jing Yang, Xiaoqing Wei*. A Generic Coordination Assembly-Enabled Nanocoating of Individual Tumor Cells for Personalized Immunotherapy, Advanced healthcare Materials, 2019, 8(17):1900474.IF=7.367

8. Yijia Liu, Xianghui Zhu, Yan Lu, Xiaoli Wang, Hongfan Sun, Chuangnian Zhang, Hongfan Sun, Guilei Ma*.Antigen‐Inorganic Hybrid Flowers-Based Vaccines with Enhanced Room Temperature Stability and Effective Anticancer Immunity, Advanced healthcare Materials, 2019, 8(21):1900660.IF=7.367

9. Lanxia Liu, Pingchuan Ma, Hai Wang, Chao Zhang, Hongfan Sun, Chun Wang, Cunxian Song, Xigang Leng, Deling Kong, Guilei Ma*. Immune responses to vaccines delivered by encapsulation into and/or adsorption onto cationic lipid-PLGA hybrid nanoparticles, Journal of Controlled Release, 2016, 225: 230-239.IF=7.786

10. Lanxia Liu, Fengqiang Cao, Xiaoxuan Liu, Hai Wang, Chao Zhang, Hongfan Sun, Chun wang, Xigang Leng, Cunxian Song, Deling Kong, Guilei Ma*. Hyaluronic Acid-Modified Cationic Lipid-PLGA Hybrid Nanoparticles as a Nanovaccine Induce Robust Humoral and Cellular Immune Responses. ACS Applied Materials & Interfaces, 2016, 8(19):11969-11979.IF=7.504

11. 发明专利:一种吲哚菁绿自组装纳米疫苗及制备方法,发明人:马桂蕾,刘兰霞,曹凤强,闫梦梦. (授权号:ZL201710254801.4) (授权公告日: 2020.4.10).发明专利:一种基于SHP2抑制剂和光敏剂的白蛋白纳米药物及其制备方法,发明人:马桂蕾; 龚咏华; 张瑾暘; 朱敦皖; 张琳华; 董霞; 吕丰.(授权号:ZL 202211127283.7(授权公告日: 2023.8.25).

12. 发明专利:一种吲哚菁绿自组装纳米疫苗及制备方法,发明人:马桂蕾,刘兰霞,曹凤强,闫梦梦. (授权号:ZL201710254801.4) (授权公告日: 2020.4.10).

13. 发明专利:一种RGD靶向卟啉聚合物纳米胶束的制备方法, 发明人:马桂蕾, 宋存先 (授权号:ZL 201310360627.3) (授权公告日: 2015.1.4).



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