沈贺，中国医学科学院生物医学工程研究所研究员，博士生导师。2009年本科毕业于中国科学技术大学，2014年在中国科学院大学获理学博士学位。此后分别在中科院苏州纳米所和美国匹兹堡大学医学院从事博士后研究工作，合作导师分别是戴建武教授和Rocky S. Tuan院士。2018年6月至2024年6月在中国科学院苏州纳米技术与纳米仿生研究所任副研究员、青年研究员、硕士生导师，入选中科院特聘研究岗位序列。

从事基于功能生物材料和干细胞调控微环境促进组织再生修复的研究。以第一/通讯作者在Adv. Funct. Mater.、Biomaterials、Bioact. Mater.等杂志发表SCI论文35篇，H指数40，总引用次数两千余次。授权中国发明专利5项；参与英文专著编著3章。作为负责人主持中国科学院战略先导专项子课题、中国科学院青年人才项目、国家自然科学基金面上项目等多项科研目，累计科研经费千余万元。

担任学术期刊Front. Bioeng. Biotech.副主编、Biomed. Mater.和J. Funct. Biomater.编委以及中国研究型医院学会神经再生与修复专业委员会委员。获江苏省333高层次人才、苏州市青年岗位能手、中科院苏州纳米所先进工作者(连续三年)、中科院苏州纳米所优秀共产党员及春晖杯创新创业大赛二等奖等荣誉和奖励。

研究方向

1. 组织器官再生微环境构建

2. 组织器官再生修复功能生物材料研发

3. 基于生物活性材料的细胞命运调控和机制解析

4. 细胞移植免疫微环境调控

代表性成果

1. Zhang Q, Zhang L#, Weng W, Qiu X, Zhuang Y, Wang H, Wei F, Dai J*, Shen H*, and Chen Y*. Restoration of motor and bladder functions after spinal cord injury via sustained wogonin release from carbon nanotube incorporated hydrogels. ACS Mater. Lett., 2024, 6, 3443−3452. (IF=9.4, Q1)

2. You ZF#, Gao X#, Kang X, Yang W, Xiong T, Li Y, Wei F, Zhuang Y, Zhang T, Sun Y, Shen H*, Dai J*. Microvascular endothelial cells derived from spinal cord promote spinal cord injury repair. Bioact. Mater., 2023, 29, 36-49. (IF=18.9, Q1)

3. Gao X, You Z, Li Y, Kang X, Yang W, Wang H, Zhang T, Zhao X, Sun Y*, Shen H*, Dai J*. Multifunctional hydrogel modulates the immune microenvironment to improve allogeneic spinal cord tissue survival for complete spinal cord injury repair. Acta Biomater., 2023, 155, 235-246. (IF=9.7, Q1)

4. Zhao X#, Gu R#, Zhao Y, Wei F, Gao X, Zhuang Y, Xiao Z, Shen H*, Dai J*. Adult spinal cord tissue transplantation combined with local tacrolimus sustained-release collagen hydrogel promotes complete spinal cord injury repair. Cell Prolif., 2023, 56(5), e13451. (IF=8.5, Q1)

5. Zhuang Y, Yang W, Zhang L, Fan C, Qiu L, Zhao Y, Chen B, Chen Y, Shen H*, Dai J*. A novel leptin receptor binding peptide tethered-collagen scaffold promotes lung injury repair. Biomaterials, 2022, 291, 121884. (IF=14.0, Q1)

6. Shen H#, Fan C#, You Z, Xiao Z, Zhao Y*, Dai J*. Advances in biomaterial-based spinal cord injury repair. Adv. Funct. Mater., 2022, 32(13) 2110628. (IF= 19.0, Q1)

7. Shen H*,#, Xu B#, Yang C, Xue W, You Z, Wu X, Ma D, Shao D, Leong K*, Dai J*. A DAMP-scavenging, IL-10-releasing hydrogel promotes neural regeneration and motor function recovery after spinal cord injury. Biomaterials 2022, 280, 121279. (IF=14.0, Q1)

8. Ma DZ, Shen H*, Chen FM, Liu WY, Zhao YN, Xiao ZF, Wu XM, Chen B, Lu JN, Shao D, Dai JW*. Inflammatory microenvironment-responsive nanomaterials promote spinal cord injury repair by targeting IRF5. Adv. Healthc. Mater., 2022,23(11), 202201319. (IF=10.0, Q1)

9. Ma DZ, Zhao YN, Huang L, Xiao ZF, Chen B, Shi Y, Shen H*, Dai JW*. A novel hydrogel-based treatment for complete transection spinal cord injury repair is driven by microglia/macrophages repopulation. Biomaterials, 2020, 237, 119830. (IF=14.0, Q1)

 10. Shen H#, Wu SY#, Chen X#, Xu B, Ma DZ, Zhao YN, Zhuang Y, Chen B, Hou XL, Li JY, Cao YD, Fu XY, Tan J, Yin W, Li J, Meng L, Shi Y, Xiao ZF*, Jiang XJ*, Dai JW*. Allotransplantation  of adult spinal cord tissues after complete transected spinal cord injury: long-term survival and functional recovery in canines. Sci China Life Sci., 2020, 63(12),1879-1886. (IF=9.1, Q1)