1、 个人简介

张明明，博士，研究员，博士生导师。

1997-2007年于南开大学高分子化学研究所获学士、硕士及博士学位。2008年至今，就职于中国医学科学院生物医学工程研究所，戴建武研究员（PI）团队成员。

长期从事医用材料设计与应用研究，研究方向：脊髓损伤修复、类器官构建、纳米递送系统等。主持及主要参与国家自然科学基金、国家重点研发计划、教育部博士点基金、天津市面上项目、协和青年基金等10余项。发表高水平学术论文55篇，获授权发明专利8项。

2、代表性成果

(1) Jiahui Lai, Dexin Kong, Yuting Liu, Jianwu Dai*, Mingming Zhang*. A flexible fibrin-based platform for driving one-day self-assembly of millimeter-sized cell-rich spheroids and their applications: an old material with new tricks. Advanced Functional Materials , 2024, 34(39): 2403507. (IF="19.0)

(2) Miaomiao Luo#, Jiahui Lai#, Enhua Zhang, Yue Ma, Runbang He, Lina Mao, Bo Deng, Junjin Zhu, Yan Ding, Jialyu Huang, Bin Xue, Qiangsong Wang, Mingming Zhang*, Pengyu Huang*. Rapid Self-Assembly Mini-livers Protect Mice Against Severe Hepatectomy-Induced Liver Failure. Advanced Science , 2024, 11(21): 2309166. (IF="14.1)

(3) Qingqing Xiong#*, Yang Bai#, Run Shi#, Jian Wang, Weiguo Xu, Mingming Zhang*, Tianqiang Song*. Preferentially released miR-122 from cyclodextrin-based star copolymer nanoparticle enhances hepatoma chemotherapy by apoptosis induction and cytotoxics efflux inhibition. Bioactive Materials , 2021, 6: 3744-3755.  (IF="16.874)

(4) Wenjuan Chen, Mingming Zhang*, Chun Wang*, Qiqing Zhang*. PEI-Based Nanoparticles for Tumor Immunotherapy via In Situ Antigen-Capture Triggered by Photothermal Therapy. ACS Applied Materials & Interfaces , 2023, 15(48): 55433–55446. (IF="9.5)

(5) Jiahui Lai, Jialin Sun, Chen Li, Jianlei Lu, Yueyi Tian, Yuting Liu, Chuanzhuang Zhao, Mingming Zhang*. H-bond-type thermo-responsive schizophrenic copolymers: The phase transition correlation with their parent polymers and the improved protein co-assembly ability. Journal of Colloid and Interface Science , 2023, 650: 1881–1892. (IF="9.9)

(6) Shunfeng Yu, Kang Liu, Yueyi Tian, Xiaoxiao Chen, Jie Zhang, Mei Gao, Jinhui Wang, Mingming Zhang,* and Chuanzhuang Zhao*. Color-Shifting Fluorescent System Based on an AIE Polymer with an Upper Critical Solution Temperature. Macromolecules , 2023, 56(11): 4278-4286. (IF="5.5)

(7) Yueyi Tian, Jiahui Lai, Chen Li, Jialin Sun, Kang Liu, Chuanzhuang Zhao*, Mingming Zhang*. Poly( N -acryloyl glycinamide-co- N -acryloxysuccinimide) Nanoparticles: Tunable Thermo-Responsiveness and Improved Bio-Interfacial Adhesion for Cell Function Regulation. ACS Applied Materials & Interfaces , 2023, 15(6): 7867–7877. (IF="9.5)

(8) Jialin Sun, Jianlei Lu, Chen Li, Yueyi Tian, Kang Liu, Lingrong Liu, Chuanzhuang Zhao*, Mingming Zhang*. Design of a UCST polymer with strong hydrogen bonds and reactive moieties for facile polymer-protein hybridization. Biomacromolecules , 2022, 23(3): 1291−1301. (IF="6.988)

(9) Yanhang Hong, Wen Zhong, Mingming Zhang*, and Hanying Zhao*. Polymerization-Induced Interfacial Self-Assembly: A Powerful Tool for the Synthesis of Micro-sized Hollow Capsules. Macromolecules , 2021, 54(24): 11238-11247. (IF="6.057)

(10) Enyu Shi#, Liya Bai#, Lujia Mao, Hanping Wang, Xiaoying Yang, Yinsong Wang, Mingming Zhang*, Changyi Li*, Yue Wang*. Self-assembled nanoparticles containing photosensitizer and polycationic brush for synergistic photothermal and photodynamic therapies against periodontitis. Journal of Nanobiotechnology , 2021, 19: 413. (IF="10.435)

3、 主要研究方向

智能型与超支化高分子材料的分子设计，旨在精确调控其智能型和其他理化性能，在分子水平理解材料与生物体之间的相互作用，最终服务于生物医学领域，包括：脊髓损伤修复、类器官构建、肿瘤治疗等。

4、社会兼职

担任教育部学位与研究生教育发展中心评审专家

中国教育发展战略学会人才发展专业委员会学术桥评审专家

重庆市科学技术局入库专家

上海市科学技术局入库专家